GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6832769 | 1 | rs4580704 | chr4:56326707 | TMEM165 | chr4:56262090-56292342:+ | 0.15 | 3.67 | 0.000266 | Personality dimensions |
| THCA | cis | rs465969 | 1 | rs4580915 | chr6:111760764 | KIAA1919 | chr6:111580482-111590259:+ | 0.48 | 5.69 | 2.21E-8 | Psoriasis |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | ANKRD13B | chr17:27916801-27941778:+ | 0.36 | 8.85 | 1.71E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | CORO6 | chr17:27941774-27948441:- | 0.51 | 12.07 | 1.87E-29 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.31 | 1.99E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | GIT1 | chr17:27900487-27916610:- | 0.28 | 6.71 | 5.4E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | LRRC37B2 | chr17:28903483-28992715:+ | 0.16 | 3.54 | 0.000433 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | SSH2 | chr17:27952965-28257018:- | 0.36 | 8.18 | 2.52E-15 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | TP53I13 | chr17:27895739-27900174:+ | 0.2 | 5.29 | 1.88E-7 | Coffee consumption (cups per day) |
| THCA | cis | rs8135828 | 1 | rs458196 | chr22:29978026 | NIPSNAP1 | chr22:29950800-29977144:- | 0.27 | 3.91 | 0.000104 | Lipid traits |
| THCA | cis | rs11723261 | 1 | rs4582105 | chr4:246342 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.47 | 1.25E-19 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs2243480 | 1 | rs458291 | chr7:65520479 | CCT6P1 | chr7:65216092-65228661:+ | 0.4 | 6.41 | 3.43E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs458291 | chr7:65520479 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.3 | 2.07E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs458291 | chr7:65520479 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.06 | 5.74E-12 | Diabetic kidney disease |
| THCA | cis | rs13315871 | 1 | rs4585221 | chr3:58415567 | PXK | chr3:58318617-58410878:+ | 0.33 | 5.77 | 1.42E-8 | Cholesterol, total |